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The study investigated the effect of hormone replacement therapy (HRT) on cognitive processes in healthy, naturally postmenopausal women.Participants were 64 volunteer postmenopausal women (27 in HRT, 37 in non-HRT group). Groups were matched for age, level of education and postmenopausal period. Duration of HRT was more than 12 months. Cognitive processes were measured through 44 scores obtained...
To compare the effects of sequential transdermal administration versus oral administration of estradiol plus NETA on serum nitric oxide (NO) levels in postmenopausal women (PMW).Eighty postmenopausal subjects without any prior hormone replacement therapy (HRT) usage were enrolled in this study. All participants were healthy, ambulatory, non-smoker and had similar life styles with dietary habits. HRT...
We analysed risk factors for high blood pressure (BP) among women around menopause.Eligible women were consecutively attending first-level outpatient menopause clinics in Italy for general counseling or treatment of menopausal symptoms. During the visit BP was measured three times. The mean of second and third of the three diastolic BP values for women was >90mm of mercury and/or reporting any...
To study the effects of different types of continuous hormone replacement therapy on carbohydrate metabolism.Postmenopausal women were treated with conjugated estrogens, 0.625mg/medroxyprogesterone acetate, 2.5 or 5mg (CEE/MPA) or tibolone 2.5mg daily for 13 28-day cycles. Serum glucose and insulin were measured before and during a 75g oral glucose tolerance test (OGTT) at baseline and after 3, 6...
Adoption of transvaginal ultrasound in usual clinical settings allowed us to find asymptomatic adnexal masses more frequently in postmenopausal women. These masses were traditionally considered as the indication of surgical excision to determine histological diagnosis. Recently, if the appearance of that is simple cyst, conservative management may be acceptable because ultrasound benign diagnosis...
The aim of this study was to evaluate the effects of isoflavone on the climacteric symptoms (Kupperman Menopausal index), vaginal pH, vaginal cytology (vaginal maturation index) and endometrium (evaluated by ultrasound and biopsy) in postmenopausal women.It was a single-center, 6-month, randomized, double-blind, estrogen-controlled trial. Seventy-nine women were randomly assigned to one of the two...
The aim of this study was to evaluate the effects of different types of hormone replacement therapy (HRT) on mammographic density.In a prospective 1-year study, 103 postmenopausal women were randomized to receive tibolone 2.5mg/die, continuous conjugated equine estrogens 0.625mg/die plus medroxyprogesterone acetate (MPA) 5mg/die or placebo. Mammograms were performed at baseline and after 12 months...
The objective of this paper is to report the prevalence and correlates of both prescription and non-prescription hormone use.Cross-sectional baseline study from a prospective cohort of 30,448 women receiving mammography in New Hampshire.Odds of prescription hormone and non-prescription hormone use.29,851 women were included; 62% reported some use of prescription hormone therapy, with current long-term...
The aim of the study was to assess skeletal status in natural and surgically induced menopausal women regarding the presence of previous osteoporotic fracture.Ninety-three females after bilateral oophorectomy in mean age of 56.8±8.3y. (48 without and 45 with fracture, groups 1 and 2, respectively) and 285 females with natural menopause in mean age of 56.4±7.0y (176 without and 109 with fracture, groups...
To elucidate if percutanous treatment with 10mg testosterone per day could enhance sexuality and psychological well-being in postmenopausal women presenting problems with low libido. Secondary to study the influence on blood lipids, hemoglobin and erythropoietin levels.Fifty-three postmenopausal women participated. As a complement to their already on-going HRT, 10mg of a testosterone gel (Testogel,...
Unsaturated fatty acids are known to have a crucial role in the pathogenesis of atherosclerosis. They are very sensitive to oxidation caused by excess free oxygen radicals and the consequent oxidative status, and it is well known that lipid and lipoprotein metabolism is markedly altered in postmenopausal women. Oxidative stress is involved in the pathophysiology of atherosclerosis and our study aim...
Objective: To evaluate changes in mammographic density and 99m Tc-sestamibi scintimammographic uptake in postmenopausal women on hormone replacement therapy (HRT).Methods: Seventy-five postmenopausal women were prospectively studied and allocated into three groups: 50 women were randomized to either Group 1 (G1, n=25), which received 2mg of 17β-oestradiol continuously combined with 1mg of...
Pilot study to compare the effects of a continuous combined hormone replacement therapy (HRT) regimen with an interrupted progestogen regimen administered transdermally, upon the endometrium of postmenopausal women, the incidence of amenorrhoea and relief of menopausal symptoms.Fifty-nine postmenopausal women aged 50–63 years were randomised to either (i) continuous combined regimen: combined oestrogen/progestogen...
Objectives: Determine which social, demographic and sexual function variables that most influence libido or desire and orgasm domains in the premenopausal and postmenopausal women.Methods: A cross-sectional analysis of 231 Colombian-born women, aged 40–62 years. The sexual function was measured by self-questionnaire. The analysis was performed by using the χ 2 -test and multivariate regression...
To evaluate and compare the relationship of body mass index (BMI) and the immunoexpression of estrogen (ER) and progesterone receptors (PR) in endometrial polyps (EP) and endometrium, in gland and stromal cells of postmenopausal women.Thirty-five postmenopausal women with benign endometrial polyps, who had not been taking medication with hormonal effects for at least 6 months, were submitted to operative...
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